275 products were found matching "K04145"!

In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia, other mutations have been associated with schizophrenia. Alternative splicing of this...

Cariprazine N-oxide is a degradation product of the atypical antipsychotic cariprazine (Cay-31446, Cay-24025). It is formed via oxidative degradation induced by hydrogen peroxide or 3-chloroperoxybenzoic acid (MCPBA). Formal Name:...

(±)-Sulpiride (CRM) (Cay-44579) is a certified reference material categorized as an atypical antipsychotic. Formulations containing (±)-sulpiride have been used in the treatment of schizophrenia, depression, and anxiety. This product is intended for analytical forensic applications. This product is also available as...

Melperone (hydrochloride) (CRM) (Cay-44822) is a certified reference material categorized as an atypical antipsychotic. This product is intended for analytical forensic applications. This product is also available as a general research tool (Cay-19770).

Description: Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels....

Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Cay-15631). Pergolide (0.025 and 0.05 mg/kg)...

Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively). It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to alpha1- and alpha2- adrenergic...

Risperidone is an atypical antipsychotic that binds to dopamine D2 receptors (Ki = 3 nM) and the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 0.12 nM). It also binds to dopamine D4, alpha1- and alpha2-adrenergic, 5-HT1C, 5-HT1D, and histamine H1 receptors (Kis = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively)....

A 5-HT2A and dopamine D2 receptor antagonist, selective for the 5-HT2A receptor over 5-HT2B and 5-HT1C receptors (Kis = 22.39, 977.24, and 1,548.82 nM, respectively) but does bind to the 5-HT1A receptor (Ki = 50 nM), selectively binds to the dopamine D2 receptor over the dopamine D1 receptor (Kis = 3 and 2,530 nM,...

Thioridazine is a typical antipsychotic. It binds to dopamine D2, histamine H1, M3 muscarinic, and alpha1- and alpha2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces...

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for alpha1 over the alpha2 subtypes (Kis = 24, 653, 163, and 391 nM for alpha1A, alpha2A, alpha2B, and alpha2C, respectively)....

Corypalmine is an isoquinoline alkaloid that has been found in F. recisa and has receptor antagonist and antifungal activities. It is an antagonist of dopamine D1, D2, D3, and D5 receptors (Kis = 199, 42. 262, and 313 nM, respectively). Corypalmine is active against C. albicans, C. glabratas, C. krusei, C....