280 products were found matching "K04145"!

(S)-Sulpiride-d3 is intended for use as an internal standard for the quantification of (S)-sulpiride by GC- or LC-MS. (S)-Sulpiride is a dopamine D2 receptor antagonist (Ki = 6.9 nM). It reduces apomorphine-induced locomotion in mice when administered at doses ranging from 4-64 mg/kg. Formulations containing...

Cariprazine N-oxide is a degradation product of the atypical antipsychotic cariprazine (Cay-31446, Cay-24025). It is formed via oxidative degradation induced by hydrogen peroxide or 3-chloroperoxybenzoic acid (MCPBA). Formal Name:...

(±)-Sulpiride (CRM) (Cay-44579) is a certified reference material categorized as an atypical antipsychotic. Formulations containing (±)-sulpiride have been used in the treatment of schizophrenia, depression, and anxiety. This product is intended for analytical forensic applications. This product is also available as...

Melperone (hydrochloride) (CRM) (Cay-44822) is a certified reference material categorized as an atypical antipsychotic. This product is intended for analytical forensic applications. This product is also available as a general research tool (Cay-19770).

Description: Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels....

In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia, other mutations have been associated with schizophrenia. Alternative splicing of this...

Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively). It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to alpha1- and alpha2- adrenergic...

Risperidone is an atypical antipsychotic that binds to dopamine D2 receptors (Ki = 3 nM) and the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 0.12 nM). It also binds to dopamine D4, alpha1- and alpha2-adrenergic, 5-HT1C, 5-HT1D, and histamine H1 receptors (Kis = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively)....

Thioridazine is a typical antipsychotic. It binds to dopamine D2, histamine H1, M3 muscarinic, and alpha1- and alpha2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces...

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for alpha1 over the alpha2 subtypes (Kis = 24, 653, 163, and 391 nM for alpha1A, alpha2A, alpha2B, and alpha2C, respectively)....

Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Cay-15631). Pergolide (0.025 and 0.05 mg/kg)...

Bromocriptine is a dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1, D2, D3, D4, and D5 receptors, respectively). It also binds to the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1D (Kis = 12.9 and 10.7 nM, respectively), as well as alpha1-adrenergic receptors (Kis =...