PF-573228

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.Formal Name: 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone. CAS Number: 869288-64-2. Synonyms: FAK Inhibitor II, Focal Adhesion Kinase Inhibitor II. Molecular Formula: C22H20F3N5O3S. Formula Weight: 491.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml. lambdamax: 292 nm. SMILES: [H]N(C1=NC(N(CC2=CC(S(=O)(C)=O)=CC=C2)[H])=C(C(F)(F)F)C=N1)C3=CC(CC4)=C(C=C3)N([H])C4=O. InChi Code: InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30). InChi Key: HESLKTSGTIBHJU-UHFFFAOYSA-N.