PF-562271

Item number	Size	Manual	Delivery time	Price
SYN-1064-M001	1 mg	-	3 - 9 business days*	106.00€
SYN-1064-M005	5 mg	-	3 - 9 business days*	198.00€
SYN-1064-M010	10 mg	-	3 - 9 business days*	289.00€
SYN-1064-M050	50 mg	-	3 - 9 business days*	856.00€
SYN-1064-M100	100 mg	-	3 - 9 business days*	-

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Soluble in DMSO or ethanol. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK... more

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Product information "PF-562271"

Soluble in DMSO or ethanol. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections. Substrate: Tyrosine

Keywords:	PF562271, PF-562,271
Supplier:	SYNkinase
Supplier-Nr:	1064

Properties

Application:	FAK / Pyk2 inhibitor
MW:	507,5 D
Formula:	C21H20F3N7O3S
Purity:	>95%
Format:	Solid

Database Information

CAS :	717907-75-0\| Matching products
KEGG ID :	K05725 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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