Penitrem A

Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of large-conductance calcium-activated potassium channels KCa1.1/BK, inhibiting the binding of charybdotoxin with an IC50 value of 1.7 µM. It is currently used to evaluate the role of KCa1.1-mediated potassium flux in various cell processes and responses.Formal Name: (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol. CAS Number: 12627-35-9. Synonyms: NSC 354845, Tremortin A. Molecular Formula: C37H44ClNO6. Formula Weight: 634.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:2): 30 mg/ml, Ethanol: 10 mg/ml. lambdamax: 235, 302 nm. SMILES: C=C(C)[C@H]1O[C@@]([C@]2(O3)[C@H]3[C@H]1O)([H])CC[C@]([C@@]2(O)CC4)(C)[C@@]([C@]4([H])C5OC(C)(C)[C@](C6)([H])[C@]7(O)[C@@]6([H])C(C8)=C)(C)C9=C5C%10=C7C8=C(Cl)C=C%10N9. InChi Code: InChI=1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,. InChi Key: JDUWHZOLEDOQSR-VCJNCYDTSA-N. Origin: Fungus/Penicillium palitans.