Pamidronate (sodium salt)

Pamidronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively). In rats, it inhibits bone resorption when used at doses of 16 µmol/kg per day, impairs long bone growth at >40 µmol/kg per day, and has anti-hypercalcemic effects in a rat hypercalcemia model. At high concentrations, pamidronate induces activation of matrix metalloproteinase-2 (MMP-2), NF-kappaB, and caspase-3, leading to cell death, which can be prevented by activated protein C. Formulations containing pamidronate have been used to treat hypercalcemia, Paget's disease, metastatic bone disease, and multiple myeloma.Formal Name: P,P'-(3-amino-1-hydroxypropylidene)bis-phosphonic acid, disodium salt. CAS Number: 57248-88-1. Synonyms: APD, CGP 23339A, Pamidronic Acid. Molecular Formula: C3H9NO7P2 . 2Na. Formula Weight: 279.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: NCCC(P(O)([O-])=O)(O)P([O-])(O)=O.[Na+].[Na+]. InChi Code: InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11,,/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11),,/q,2*+1/p-2. InChi Key: CEYUIFJWVHOCPP-UHFFFAOYSA-L.