P32/98 (hemifumarate)

The glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are responsible for a majority of nutrient-stimulated insulin secretion. After being released into the circulation, GIP and GLP-1 are inactivated by the circulating enzyme dipeptidyl peptidase IV (DPP IV). DPP IV inhibitors have emerged as a new class of experimental antidiabetic agents. P32/98 is a competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM). At 20 mg/kg/day, it has been used to improve glucose tolerance, insulin sensitivity, and beta-cell glucose responsiveness in diabetic rat models.Formal Name: (2S,3S)-2-amino-3-methyl-1-(3-thiazolidinyl)-1-pentanone, 2E-butenedioate (2:1). CAS Number: 251572-86-8. Molecular Formula: C9H18N2OS . 1/2C4H4O4. Formula Weight: 260.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C([C@@H](N)[C@@H](C)CC)N1CCSC1.OC(/C=C/C(O)=O)=O. InChi Code: InChI=1S/C9H18N2OS.C4H4O4/c1-3-7(2)8(10)9(12)11-4-5-13-6-11,5-3(6)1-2-4(7)8/h7-8H,3-6,10H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1+/t7-,8-,/m0./s1. InChi Key: ZSOPWZQRZHWYFY-NUXPJIRBSA-N.