Oxyresveratrol

Resveratrol is a potent phenolic antioxidant found in the skin of grapes and red wine that has anti-proliferative, anti-inflammatory, and cardioprotective properties. Oxyresveratrol is a naturally occurring analog of resveratrol found in mulberry wood. It effectively scavenges H2O2, NO (IC50 = 45.3 µM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 µM). At 10 mg/kg, oxyresveratrol acts as a neuroprotectant, reducing brain infarct volume and reducing cytochrome c release and caspase-3 activation in an in vivo model of stroke. Oxyresveratrol also has depigmenting effects by effectively inhibiting tyrosinase activity, which catalyzes the rate-limiting step in synthesizing melanin pigments (IC50s = 1.2 and 52.7 µM in mushroom and mouse melanoma B-16 cells, respectively). It is 32-fold more potent than kojic acid, a depigmenting agent used in cosmetic materials with skin-whitening effects and medical agents used to treat hyperpigmentation disorders.Formal Name: 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-1,3-benzenediol. CAS Number: 29700-22-9. Synonyms: trans-2',3,4',5-Tetramethoxystilbene. Molecular Formula: C14H12O4. Formula Weight: 244.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): < 0.1 mg/ml. lambdamax: 220, 302, 329 nm. SMILES: OC1=CC(O)=CC(/C=C/C2=C(O)C=C(O)C=C2)=C1. InChi Code: InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+. InChi Key: PDHAOJSHSJQANO-OWOJBTEDSA-N.