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Larger quantity required? Request bulk
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates... more
Product information "OTSSP167 (hydrochloride)"
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes. MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors. OTSSP167 is a potent inhibitor of MELK (IC50 = 0.41 nM). It suppresses the growth of diverse cancer cell lines at low nanomolar concentrations. It also blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel. OTSSP167 is also effective in vivo when delivered either orally or intravenously, suppressing the growth of xenograft tumors in mice.Formal Name: 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethan-1-one, monohydrochloride. CAS Number: 1431698-10-0. Molecular Formula: C25H28Cl2N4O2 . HCl. Formula Weight: 523.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 220, 305 nm. SMILES: CC(C1=CN=C(C=CC(C2=CC(Cl)=C(O)C(Cl)=C2)=N3)C3=C1N[C@H]4CC[C@H](CN(C)C)CC4)=O.Cl. InChi Code: InChI=1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3,/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29),1H/t15-,17-,. InChi Key: XDGWHISAOWEFML-BFLZMHAMSA-N.
Keywords: | 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethan-1-one, monohydrochloride |
Supplier: | Cayman Chemical |
Supplier-Nr: | 16873 |
Properties
Application: | MELK inhibitor |
MW: | 523.9 D |
Formula: | C25H28Cl2N4O2 . HCl |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 1431698-10-0| Matching products |
KEGG ID : | K08799 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H317, H318, H334, H335, H341, H361, H370, H413 |
P Phrases: | P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+352, P304+340, P304+341, P305+351+338, P308+311, P308+313, P310, P312, P321, P333+313, P342+311, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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