Optovin

Optovin is a TRPA1 ligand that can be reversibly photoactivated by violet (405 nm) light. Optovin-treated zebrafish respond to light with vigorous motor excitation (EC50 = 2 µM). Optovin-treated mouse dorsal root ganglia neurons displayed increased intracellular calcium following stimulation with light but only in wild-type TRPA1 cells. Optovin has been used to study the role of TRPA1 in the response of cardiac myocytes to reperfusion injury.Formal Name: 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone. CAS Number: 348575-88-2. Molecular Formula: C15H13N3OS2. Formula Weight: 315.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml, DMSO: 20 mg/ml. lambdamax: 290, 420 nm. SMILES: CC1=CC(/C=C2SC(N([H])C/2=O)=S)=C(C)N1C3=CN=CC=C3. InChi Code: InChI=1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)/b13-7+. InChi Key: YISGMOZSGOGYOU-NTUHNPAUSA-N.