54 products were found matching "K04984"!

Transient receptor potential cation channel A1 (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds. HC-030031 is a selective TRPA1 blocker, antagonizing...

The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. A-967079 is a potent, selective, and bioavailable inhibitor of the...

PF-4840154 is a transient receptor potential ankyrin 1 (TRPA1) agonist. It induces calcium influx into HEK293 cells expressing recombinant human or rat TRPA1 (EC50s = 23 and 97 nM, respectively). Intraplantar injection of PF-4840154 (30 nmol) increases paw licking time in mice in a TRPA1-dependent manner.Formal...

An aqueous solution (with 0.1 % formic acid as a stabilizer) of allicin at 25 mg/mL. The main biologically active compound in garlic. It exerts various biological effects, including antiproliferative, chemopreventive, antioxidant, antihyperlipidaemic and antihypertensive effects. It has been shown to inhibit the...

JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 µM.Formal Name:...

Supercinnamaldehyde is an activator of the transient receptor potential ankyrin 1 (TRPA1) channel (EC50 = 0.8 µM) and an analog of cinnamaldehyde. TRPA1 is a nociceptor expressed on sensory neurons and is activated by hot and cold temperatures, mechanical stimuli, and pain.Formal Name:...

AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.Formal Name: 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime. CAS Number:...

Polygodial is a sesquiterpene dialdehyde isolated from the leaves of certain peppers and related plants. Noted for its broad antifungal properties, polygodial is also cytotoxic against bacteria, algae, and sea squirts. In mammals, polygodial produces a pungent flavor, activates the transient receptor potential...

Description: A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively. Target: TRP/TRPV Channel. Smiles: CC\C(=N/O)\C(\C)=C\c1ccc(F)cc1. References: McGaraughty S, Chu KL, Perner RJ,et al.TRPA1 modulation of...

Isolated from Umbellularia californica Nutt. Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and...

Optovin is a TRPA1 ligand that can be reversibly photoactivated by violet (405 nm) light. Optovin-treated zebrafish respond to light with vigorous motor excitation (EC50 = 2 µM). Optovin-treated mouse dorsal root ganglia neurons displayed increased intracellular calcium following stimulation with light but only in...

The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse, potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. TCS 5861528 is a selective TRPA1 blocker that antagonizes...