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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay25754-500 | 500 µg | - |
6 - 10 business days* |
306.00€
|
|||
Cay25754-1 | 1 mg | - |
6 - 10 business days* |
546.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Ondansetron-13C-d3 is intended for use as an internal standard for the quantification of... more
Product information "Ondansetron-13C-d3"
Ondansetron-13C-d3 is intended for use as an internal standard for the quantification of ondansetron by GC- or LC-MS. Ondansetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 receptor (Ki = 1.6 nM). It is selective for the 5-HT3 receptor over the 5-HT1A-D, 5-HT2, and 5-HT4 receptors (Kis = >1,200 nM). It inhibits 5-HT-induced depolarization of isolated rat vagus nerve and contraction of isolated guinea pig ilium longitudinal muscle-myenteric plexus preparations in a concentration-dependent manner ex vivo. In a ferret model of cisplatin-induced emesis, ondansetron reduces the number of retching and vomiting episodes and increases the latency time to vomit when administered at a dose of 0.01 mg/kg and eliminates retching and vomiting when administered at a dose of 0.1 mg/kg. Ondansetron (0.5 and 1 mg/kg) also decreases immobility time in a forced swim test and increases time spent in the light chamber and latency to leave the light chamber in the light/dark exploration test in a mouse model of diabetes induced by streptozotocin (STZ, Cay-13104), indicating antidepressant-like and anxiolytic activities. Formulations containing ondansetron have been used in the treatment of nausea and vomiting associated with chemotherapy, radiotherapy, or following surgery.Formal Name: 9-(methyl-13C-d3)-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one. CAS Number: 2699607-85-5. Molecular Formula: C17[13C]H16D3N3O. Formula Weight: 297.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: 0.1 mg/ml. SMILES: O=C1C(CN2C(C)=NC=C2)CCC3=C1C(C=CC=C4)=C4N3[13C]([2H])([2H])[2H]. InChi Code: InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3/i2+1D3. InChi Key: FELGMEQIXOGIFQ-JVXUGDAPSA-N.
Keywords: | 9-(methyl-13C-d3)-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 25754 |
Properties
Application: | 5-HT3 receptor antagonist, GC-MS, LC-MS, internal standard |
MW: | 297.4 D |
Formula: | C17[13C]H16D3N3O |
Purity: | >99% deuterated forms (d1-d3) |
Format: | Solid |
Database Information
CAS : | 2699607-85-5| Matching products |
KEGG ID : | K04819 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H312, H315, H319, H332 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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