Oltipraz

Oltipraz, originally identified as an antischistosomiasis agent, is a potent anticarcinogen in a variety of animal models of cancer at concentrations of ~200 mg/kg. It is an effective inducer of phase I and II detoxifying enzymes, including glutathione S-transferases, UDP-glucuronosyltransferases, NAD(P)H:quinone oxidoreductase, microsomal epoxide hydrolase, and aflatoxin aldehyde reductase. Induction of these metabolic enzymes by oltipraz has been linked to the transcription factor nuclear factor E2-related factor 2 and its activation of the antioxidant response element. In mice, oltipraz at 150 mg/kg can also induce expression of CYP2B, a gene regulated by the constitutive androstane receptor, a transcription factor important in the detoxification of endobiotic and xenobiotic substances.Formal Name: 4-methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione. CAS Number: 64224-21-1. Synonyms: NSC 347901, RP 35972. Molecular Formula: C8H6N2S3. Formula Weight: 226.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 16 mg/ml. lambdamax: 227, 301, 441 nm. SMILES: CC1=C(SSC1=S)C2=NC=CN=C2. InChi Code: InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3. InChi Key: CKNAQFVBEHDJQV-UHFFFAOYSA-N.