NVP-BEP800

NVP-BEP800 is an inhibitor of heat shock protein 90 (Hsp90, IC50 = 58 nM for recombinant human Hsp90beta). It is selective for Hsp90 over the chaperones GRP94 and TRAP1 (IC50s = 4.1 and 5.5 µM, respectively). NVP-BEP800 inhibits the growth of BT474, SK-BR-3, MCF-7, MDA-MB-157, MDA-MB-231, MDA-MB-468, and BT-20 breast cancer cells (GI50s = 53, 56, 118, 89, 190, 173, and 162 nM, respectively). It reduces levels of the Hsp90 target proteins HER2 and Raf-1 in MCF-7 cells. NVP-BEP800 induces apoptosis and attenuates X-ray-induced increases in Hsp70 levels in T98G glioblastoma cells. NVP-BEP800 (15-50 mg/kg) reduces tumor volume in A375 melanoma and BT474 breast cancer mouse xenograft models. It also reduces tumor volume in an L1T2 Kaposi sarcoma mouse xenograft model.Formal Name: 2-amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl-thieno[2,3-d]pyrimidine-6-carboxamide. CAS Number: 847559-80-2. Molecular Formula: C21H23Cl2N5O2S. Formula Weight: 480.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, Ethanol: 5 mg/mL. lambdamax: 230, 264, 302, 345 nm. SMILES: ClC1=CC(Cl)=C(OCCN2CCCC2)C=C1C3=C4C(SC(C(NCC)=O)=C4)=NC(N)=N3. InChi Code: InChI=1S/C21H23Cl2N5O2S/c1-2-25-19(29)17-10-13-18(26-21(24)27-20(13)31-17)12-9-16(15(23)11-14(12)22)30-8-7-28-5-3-4-6-28/h9-11H,2-8H2,1H3,(H,25,29)(H2,24,26,27). InChi Key: WJUNQSYQHHIVFX-UHFFFAOYSA-N.