NVP-2

NVP-2 is an inhibitor of the Cdk9/cyclin T1 complex (IC50 = 50s = 0.584->10 µM), as well as over a panel of 468 kinases at 1 µM. NVP-2 (250 nM) inhibits the proliferation of, and induces apoptosis in, MOLT-4 human acute lymphoblastic leukemia cells.Formal Name: 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile. CAS Number: 1263373-43-8. Molecular Formula: C27H37ClN6O2. Formula Weight: 513.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: soluble. lambdamax: 225, 255, 324 nm. SMILES: COC[C@@H](C)N[C@H](CC1)CC[C@@H]1NC2=CC(C3=NC(NCC4(CCOCC4)C#N)=CC=C3)=C(Cl)C=N2. InChi Code: InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1. InChi Key: XWQVQSXLXAXOPJ-NJDAHSKKSA-N.