- Search results for K02211
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55 products were found matching "K02211"!
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Item number: Cay39845-1
P276-00 is an inhibitor of cyclin-dependent kinase 9 (Cdk9), Cdk4, and Cdk1 (IC50s = 0.020, 0.063, and 0.079 µM, respectively). It is selective for these CDKs over Cdk2/cyclin E, Cdk2/cyclin A, Cdk6, and Cdk7 (IC50s = 2.54, 0.224, 0.396, and 2.87 µM, respectively), as well as a panel of eight other kinases. P276-00...
Keywords: | Riviciclib, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one,... |
Application: | Cdk9 / Cdk4 / Cdk1 inhibitor |
CAS | 920113-03-7 |
MW: | 438.3 D |
From 119.00€
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Item number: Cay33306-1
AZD 4573 is an inhibitor of cyclin-dependent kinase 9 (Cdk9, IC50 = 14 nM). It is selective for Cdk9 over Cdk1, Cdk7, Cdk4/6, and Cdk2 (IC50s = 370, 1,100, 1,100, and >10,000 nM, respectively). AZD 4573 (100 nM) induces apoptosis in MV4-11 acute myeloid leukemia (AML) cells. In vivo, AZD 4573 (15 mg/kg every other...
Keywords: | (1S,3R)-3-(acetylamino)-N-[5-chloro-4-(5,6-dihydro-5,5-dimethyl-4H-pyrrolo[1,2-b]pyrazol-3-yl)-2-pyridinyl]-cyclohexanecar... |
Application: | Cdk9 inhibitor |
CAS | 2057509-72-3 |
MW: | 429.9 D |
From 77.00€
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Item number: BPS-79628-1
Cyclin-dependent kinase 9 (CDK9) is the catalytic subunit of the positive transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of RNA polymerase II, a key player in the production of mature RNA. The CDK9 Assay Kit is designed to measure CDK9/CyclinT activity for screening and...
Keywords: | C-2K, CDC2L4, Cyclin-dependent kinase 9, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Cell... |
Application: | Enzyme kinetics, drug discovery, HTS |
Species reactivity: | human |
From 847.00€
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Item number: Cay10009197-5
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa...
Keywords: | Alvocidib, HL 275, HMR 1275, L-868,275,... |
CAS | 131740-09-5 |
MW: | 438.3 D |
From 66.00€
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Item number: A303-492A
Protein function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD...
Keywords: | Anti-C-2K, Anti-CDK9, Anti-CDC2L4, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: A303-493A-T
Protein function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD...
Keywords: | Anti-C-2K, Anti-CDK9, Anti-CDC2L4, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein... |
Application: | WB, IP, IHC |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 164.00€
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Item number: Cay10011247-5
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. CAY10574...
Keywords: | 4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol |
Application: | CDK9 inhibitor |
CAS | 140651-18-9 |
MW: | 218.2 D |
From 34.00€
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Item number: Cay17904-1
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity...
Keywords: | BMS-387032, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide |
Application: | Cdk9 / Cdk2 / Cdk7 inhibitor |
CAS | 345627-80-7 |
MW: | 380.5 D |
From 60.00€
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Item number: Cay14707-10
Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively. Compared to the...
Keywords: | SCH 727965, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2S-piperidineethanol |
Application: | CDK1 / CDK2 / CDK5 / CDK9 inhibitor |
CAS | 779353-01-4 |
MW: | 396.5 D |
From 125.00€
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Item number: 100-401-167
Protein function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD...
Keywords: | Anti-CDK9, Anti-C-2K, Anti-CDC2L4, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein... |
Application: | ELISA, IHC, IP, WB |
Host: | Rabbit |
Species reactivity: | human, rat, mouse |
684.00€
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Item number: 600-401-996
Protein function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD...
Keywords: | Anti-phospho-CDK9, Anti-phospho-C-2K, Anti-phospho-CDC2L4, EC=2.7.11.22, EC=2.7.11.23, Anti-phospho-Cyclin-dependent... |
Application: | ELISA, IP, WB |
Host: | Rabbit |
Species reactivity: | human |
684.00€
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Item number: NSJ-R32122
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was...
Keywords: | Anti-CDK9, Anti-C-2K, Anti-CDC2L4, EC=2.7.11.23, EC=2.7.11.22, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein... |
Application: | WB, IHC (paraffin) |
Host: | Rabbit |
Species reactivity: | human, rat |
755.00€
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