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NSC-74859 is an inhibitor of pSTAT3 that exhibits anticancer chemotherapeutic, antiviral, anti-fibrotic, and nephroprotective activities. NSC-74859 enhances the toxicity of doxorubicin by inhibiting the epithelial-to-mesenchymal transition (EMT) in vitro, it also enhances the efficacy of cetuximab in hepatic carcinoma cells. In cellular and animal models of hepatocellular cancer, NSC-74859 suppresses cell proliferation and inhibits tumor growth of xenografts. Inhibition of pSTAT3 results in decreased expression of genes encoding cyclin D1, Bcl-xl, and survivin. Additionally, NSC-74859 inhibits replication of varicella-zoster virus (VZV), a herpesvirus. In animal models of kidney injury, NSC-74859 decreases infiltration of inflammatory cells, decreases expression of fibronectin, smooth muscle actin, and collagen type-1 proteins, and inhibits proliferation, together, this increases apoptosis in renal interstitial fibroblasts.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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