Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities. STAT signaling is also suspected...

NSC-74859 is an inhibitor of pSTAT3 that exhibits anticancer chemotherapeutic, antiviral, anti-fibrotic, and nephroprotective activities. NSC-74859 enhances the toxicity of doxorubicin by inhibiting the epithelial-to-mesenchymal transition (EMT) in vitro, it also enhances the efficacy of cetuximab in hepatic...

Description: S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 µM) and low effect towards STAT1/5. Target: STAT. Smiles: Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc1ccc(C(O)=O)c(O)c1. References: Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening,...