NSC 697923

NSC 697923 is a selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro. It also inhibits NF-kappaB activation by PMA and other agonists, presumably through its effects on Ubc13. NSC 697923 blocks proliferation and induces apoptosis in diffuse large B cell lymphoma and neuroblastoma cells. It has antitumor efficacy in vivo in neuroblastoma orthotopic xenografts, when given intraperitoneally.Formal Name: 2-[(4-methylphenyl)sulfonyl]-5-nitro-furan. CAS Number: 343351-67-7. Molecular Formula: C11H9NO5S. Formula Weight: 267.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CC1=CC=C(S(C2=CC=C([N+]([O-])=O)O2)(=O)=O)C=C1. InChi Code: InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3. InChi Key: GAUHIPWCDXOLCZ-UHFFFAOYSA-N.