Description: NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of...

Synthetic. Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.

NSC 697923 is a selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro. It also inhibits NF-kappaB activation by PMA and other agonists, presumably through its effects on Ubc13. NSC 697923...