NF449 (sodium salt)

NF449 is an analog of suramin that selectively inhibits P2X1 purinergic receptors (pIC50 = 6.3) with a potency 19-fold greater than at P2X3, P2Y1, P2Y2, or P2Y11. Through selective inhibition of the P2X1 receptor, 10 mg/kg NF449 has been used to decrease intravascular platelet aggregation in a mouse model of systemic thromboembolism. NF449 has also demonstrated selective antagonism of the Gsalpha-subunit G protein, which suppresses the association rate of GTPgammaS binding to Gsalpha-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to certain GPCRs.Formal Name: 4,4',4'',4'''-[carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakis-1,3-benzenedisulfonic acid, octasodium salt. CAS Number: 627034-85-9. Molecular Formula: C41H24N6O29S8 . 8Na. Formula Weight: 1505.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 277 nm. SMILES: O=C(NC1=CC(C(NC2=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C2)=O)=CC(C(NC3=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C3)=O)=C1)NC4=CC(C(NC5=CC=C(S([O-])(=O)=O)C=C5S([O-])(=O)=O)=O)=CC(C(NC6=CC=C(S([O-])(=O)=O)C=C6S([O-])(=O)=O)=O)=C4.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C41H32N6O29S8.8Na/c48-37(44-29-5-1-25(77(53,54)55)15-33(29)81(65,66)67)19-9-20(38(49)45-30-6-2-26(78(56,57)58)16-34(30)82(68,69)70)12-23(11-19)42-41(52)43-24-13-21(39(50)46-31-7-3-27(79(59,60)61)17-35(31)83(71,72)73)10-22(14-24)40(51)47-32-8-4-28(80(62,63)64)18-36(32)84(74,75)76,,,,,,,,/h1-18H,(H,44,48)(H,45,49)(H,46,50)(H,47,51)(H2,42,43,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76),,,,,,,,/q,8*+1/p-8. InChi Key: KCBZSNWCUJBMHF-UHFFFAOYSA-F.