N,N'-Dicyclohexylurea

Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (sEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). N,N' Dicyclohexylurea (DCU) is a selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively. At 10 µM, DCU blocks the hydrolysis of cis- and trans-EETs by rat red blood cells and porcine coronary endothelial cells as well as completely inhibits 14,(15)-EET-induced PPARalpha activation.Formal Name: N,N'-dicyclohexyl-urea. CAS Number: 2387-23-7. Synonyms: DCU, NSC 17013. Molecular Formula: C13H24N2O. Formula Weight: 224.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: O=C(NC1CCCCC1)NC2CCCCC2. InChi Code: InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16). InChi Key: ADFXKUOMJKEIND-UHFFFAOYSA-N.