N-desmethyl Regorafenib N-oxide

N-desmethyl Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib (Cay-18498). It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. N-desmethyl Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAF in vitro, as well as inhibits tumor growth in HT-29 and MDA-MB-231 mouse xenograft models when administered at a dose of 1 mg/kg.Formal Name: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-2-pyridinecarboxamide 1-oxide. CAS Number: 835621-12-0. Molecular Formula: C20H13ClF4N4O4. Formula Weight: 484.8. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 264 nm. SMILES: O=C(C1=CC(OC2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2)=CC=[N]1=O)N. InChi Code: InChI=1S/C20H13ClF4N4O4/c21-14-3-1-10(7-13(14)20(23,24)25)27-19(31)28-16-4-2-11(8-15(16)22)33-12-5-6-29(32)17(9-12)18(26)30/h1-9H,(H2,26,30)(H2,27,28,31). InChi Key: JPEWXTSDCNCZOD-UHFFFAOYSA-N.