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Item number: Cay35102-1

N-desmethyl Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib (Cay-18498). It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. N-desmethyl Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAF in vitro, as well as inhibits tumor growth in HT-29 and...

Keywords:	4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-2-pyridinecarboxamide 1-oxide
Application:	Regorafenib active metabolite, multi-kinase inhibitor
CAS	835621-12-0
MW:	484.8 D

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