MY-5445

MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.Formal Name: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine. CAS Number: 78351-75-4. Molecular Formula: C20H14ClN3. Formula Weight: 331.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 215, 336 nm. SMILES: ClC1=CC=CC(NC(C2=C3C=CC=C2)=NN=C3C4=CC=CC=C4)=C1. InChi Code: InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24). InChi Key: CEHQLKSLMFIHBF-UHFFFAOYSA-N.