100 products were found matching "K13762"!

Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5, IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 and...

A PDE5 inhibitor and an active metabolite of lodenafil carbonate, enhances acetylcholine-induced relaxation of isolated human corpus cavernosum and rabbit cavernosal strips precontracted with phenylephrine (EC50s = 676 and 589 nM, respectively). Formulation: A solid. InChI:...

Chloropretadalafil is an intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor tadalafil (Cay-14024).. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: Ethanol: Slightly soluble: 0.1-1 mg/ml.

Active human PDE5A1 (GenBank Accession No. NM_001083), full length, with N-terminal GST tag, MW=126 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively. It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 µM, respectively). Sildenafil reverses glucose-induced decreases...

The PDE5A Assay Kit is designed for identification of inhibitors of PDE5A using fluorescence polarization. Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE5A, also known as cGMP-inhibited phosphodiesterase, has been implicated in cardiovascular function and...

Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells. It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and...

White to off-white powder. Soluble in DMSO (20mg/ml). Potent cGMP-specific phosphodiesterase inhibitor that is highly selective for PDE5. It inhibits PDE5 activity in isolated rabbit platelets with an IC50 value of 3.6nM (3nM in human corpus cavernosum) compared to inhibition of PDE1 and PDE3 activities (IC50s =...

Tadalafil-d3 is intended for use as an internal standard for the quantification of tadalafil (Cay-14024) by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5, IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11...

N-desmethyl Sildenafil is a major metabolite of sildenafil (Cay-10008671, Cay-14008). N-desmethyl Sildenafil is formed via oxidative metabolism of sildenafil by the cytochrome (CYP) P450 isoforms CYP3A4, CYP3A5, and CYP3A7.Formal Name:...

The PDE5A1 Assay Kit is designed for identification of PDE5A1 inhibitors sing fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE5A to the binding agent. PDE5A catalyzes the hydrolysis of the phosphodiester bond in dye-labeled cyclic guanosine...

MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.Formal Name:...