MPC-6827 (hydrochloride)

MPC-6827 is an inhibitor of tubulin polymerization with anticancer activity. It inhibits tubulin polymerization in a cell-free assay when used at concentrations of 0.5, 5, and 50 µM, as well as in A549 cells when used at a concentration of 10 nM. MPC-6827 induces apoptosis in T47D, HCT116, and SNU-398 cancer cells (EC50s = 2, 3, and 2 nM, respectively). In vivo, MPC-6827 (2.5-10 mg/kg) reduces tumor growth in MX-1, OVCAR-3, MIA PaCa-2, MCF-7, HT-29, and MDA-MB-435 mouse xenograft models.Formal Name: N-(4-methoxyphenyl)-N,2-dimethyl-4-quinazolinamine, monohydrochloride. CAS Number: 917369-31-4. Synonyms: Verubulin. Molecular Formula: C17H17N3O . HCl. Formula Weight: 315.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Water: 100 mM. lambdamax: 223, 334 nm. SMILES: COC(C=C1)=CC=C1N(C)C2=C3C=CC=CC3=NC(C)=N2.Cl. InChi Code: InChI=1S/C17H17N3O.ClH/c1-12-18-16-7-5-4-6-15(16)17(19-12)20(2)13-8-10-14(21-3)11-9-13,/h4-11H,1-3H3,1H. InChi Key: VYUWDIKZJLOZJL-UHFFFAOYSA-N.