MoTP

MoTP, known more formally as 4-(4-morpholinobutylthio)phenol, is used to ablate larval melanocytes in zebrafish in order to study melanocyte regeneration. MoTP is converted to a cytotoxin in cells with high tyrosinase activity, which in the zebrafish embryo are limited to melanoblasts and newly formed melanocytes. The wash-out of MoTP allows regeneration through the proliferation of melanocyte stem cells.Formal Name: 4-[[4-(4-morpholinyl)butyl]thio]-phenol. CAS Number: 57055-82-0. Synonyms: 4-(4-Morpholinylbutylthio)phenol. Molecular Formula: C14H21NO2S. Formula Weight: 267.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.3 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 229, 257 nm. SMILES: OC1=CC=C(SCCCCN2CCOCC2)C=C1. InChi Code: InChI=1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2. InChi Key: YHKNLUTUXZDOQI-UHFFFAOYSA-N.