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Moclobemide is a reversible inhibitor of MAO-A that exhibits antidepressant, anti-inflammatory, antinociceptive, and neuromodulatory activities. Moclobemide decreases immobility time in animals undergoing the forced swim test and suppresses LPS-induced increases in IL-1 and TNF- expression in glial cells. Additionally, moclobemide increases latency time in animal models of thermal pain through an 2-adrenergic receptor-mediated pathway. Moclobemide also induces hippocampal neurogenesis, upregulating progenitor cell proliferation and expression of BDNF in vitro.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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