MLR-1023

MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM). It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test. This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity. MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.Formal Name: 5-(3-methylphenoxy)-2(1H)-pyrimidinone. CAS Number: 41964-07-2. Synonyms: CP 26,154, NSC 314335. Molecular Formula: C11H10N2O2. Formula Weight: 202.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 225, 276, 330 nm. SMILES: CC1=CC=CC(OC2=CN([H])C(N=C2)=O)=C1. InChi Code: InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14). InChi Key: HJQILFPVRNHTIG-UHFFFAOYSA-N.