MLN2480

MLN2480 is an orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models. It shows antitumor activity in melanoma, colon, lung, and pancreatic cancer xenograft models. MLN2480 demonstrates synergistic activity with TAK-733, an allosteric MEK kinase inhibitor.Formal Name: 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide. CAS Number: 1096708-71-2. Synonyms: BIIB-024, TAK-580. Molecular Formula: C17H12Cl2F3N7O2S. Formula Weight: 506.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 237, 276, 303 nm. SMILES: NC1=NC=NC(C(N[C@H](C)C2=NC=C(C(NC3=NC=C(Cl)C(C(F)(F)F)=C3)=O)S2)=O)=C1Cl. InChi Code: InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1. InChi Key: VWMJHAFYPMOMGF-ZCFIWIBFSA-N.