- Search results for K08845
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39 products were found matching "K08845"!
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Item number: BPS-40010
Active human A-RAF (GenBank Accession No. NM_001654), amino acids 282-end, containing the mutations YY301-302DD, MW=63.6 kDa, expressed in an Baculovirus infected Sf9 cell expression system.
Keywords: | ARAF, ARAF1, EC=2.7.11.1, Proto-oncogene Pks, Proto-oncogene A-Raf, Proto-oncogene A-Raf-1, Serine/threonine-protein... |
Application: | Enzyme kinetics, inhibitor screening |
MW: | 63.6 kD |
569.00€
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Item number: Cay21504-5
LY3009120 is an inhibitor of Raf kinases, including A-Raf, B-Raf, and c-Raf (IC50s = 44, 31-47, and 42 nM, respectively, in whole cell lysates). It also inhibits B-Raf mutants V600E and V600E+G468A (IC50s = 5.8 and 17 nM, respectively, in biochemical assays). LY3009120 induces Raf dimerization and, unlike...
Keywords: | DP-4978, N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-urea |
Application: | Raf inhibitor |
CAS | 1454682-72-4 |
MW: | 424.5 D |
From 189.00€
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Item number: ARG57359.100
Protein function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. [The UniProt Consortium]
Keywords: | Anti-ARAF, Anti-ARAF1, EC=2.7.11.1, Anti-Proto-oncogene Pks, Anti-Proto-oncogene A-Raf, Anti-Proto-oncogene A-Raf-1,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
624.00€
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Item number: A303-103A
Protein function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. [The UniProt Consortium]
Keywords: | Anti-ARAF, Anti-ARAF1, EC=2.7.11.1, Anti-Proto-oncogene Pks, Anti-Proto-oncogene A-Raf, Anti-Proto-oncogene A-Raf-1,... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: A303-104A
Protein function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. [The UniProt Consortium]
Keywords: | Anti-ARAF, Anti-ARAF1, EC=2.7.11.1, Anti-Proto-oncogene Pks, Anti-Proto-oncogene A-Raf, Anti-Proto-oncogene A-Raf-1,... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay19675-1
MLN2480 is an orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models. It shows antitumor activity in melanoma, colon, lung, and pancreatic cancer xenograft models. MLN2480 demonstrates synergistic activity with TAK-733, an allosteric MEK kinase...
Keywords: | BIIB-024, TAK-580,... |
Application: | Selective pan-Raf inhibitor |
CAS | 1096708-71-2 |
MW: | 506.3 D |
From 130.00€
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Item number: Cay17807-1
L-779,450 is an ATP-competitive B-Raf inhibitor (IC50 = 10 nM, Kd = 2.4 nM) that displays >7, >30, and >70-fold selectivity over p38alpha, GSK3beta, and Lck, respectively. It has been shown to inhibit cell proliferation both in B-Raf mutated and wild-type melanoma cell lines, as well as to enhance tumor necrosis...
Keywords: | Raf Kinase Inhibitor IV, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol |
Application: | Raf kinase inhibitor |
CAS | 303727-31-3 |
MW: | 347.8 D |
From 43.00€
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Item number: NSJ-RQ5320
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The ARAF proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. [RefSeq] Protein function: Involved in the transduction of mitogenic signals from the cell membrane...
Keywords: | Anti-ARAF, Anti-ARAF1, EC=2.7.11.1, Anti-Proto-oncogene Pks, Anti-Proto-oncogene A-Raf, Anti-Proto-oncogene A-Raf-1,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
755.00€
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Item number: G-CBCAB01365.96
A-RAF (Phospho-Tyr302) Colorimetric Cell-Based ELISA Kit Protein function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. [The UniProt Consortium]
Keywords: | ARAF, ARAF1, EC=2.7.11.1, Proto-oncogene Pks, Proto-oncogene A-Raf, Proto-oncogene A-Raf-1, Serine/threonine-protein... |
Application: | In-cell ELISA |
641.00€
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Item number: E-AB-66772.120
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Protein function: Involved in the transduction of mitogenic signals from the...
Keywords: | Anti-ARAF, Anti-ARAF1, EC=2.7.11.1, Anti-Proto-oncogene Pks, Anti-Proto-oncogene A-Raf, Anti-Proto-oncogene A-Raf-1,... |
Application: | IF |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 198.00€
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Item number: G-CAB0180.100
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 352.00€
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Item number: G-CAB16346.100
WB 1:500 - 1:2000, IF 1:50 - 1:200. Protein function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. [The UniProt Consortium]
Keywords: | Anti-ARAF, Anti-ARAF1, EC=2.7.11.1, Anti-Proto-oncogene Pks, Anti-Proto-oncogene A-Raf, Anti-Proto-oncogene A-Raf-1,... |
Application: | WB, IF |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 352.00€
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