ML-351

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. ML-351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2. ML-351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.Formal Name: 5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile. CAS Number: 847163-28-4. Synonyms: CID-664510. Molecular Formula: C15H11N3O. Formula Weight: 249.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 5 mg/ml. lambdamax: 234, 344 nm. SMILES: CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2. InChi Code: InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3. InChi Key: DYXYXTDIFMDJIR-UHFFFAOYSA-N.