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ML-314 is a neurotensin-1 receptor (NTS1) agonist. It is selective for NTS1 over NTS2 in a cell-based assay of receptor/beta-arrestin complex formation (EC50s = 2 and >80 µM, respectively) but is inactive in an NTS1 calcium flux assay (EC50 = >80 µM) indicating that, in contrast to other NTS1 agonists, it does not signal through the traditional Gq-coupled pathway. ML-314 is also a positive allosteric modulator of NTS1 that increases binding of radiolabeled neurotensin (Cay-24717) to NTS1 in a concentration-dependent manner. It reduces locomotion in dopamine transporter knockout mice and methamphetamine-exposed mice when administered at doses of 20 and 10 to 30 mg/kg, respectively. ML-314 (30 mg/kg) also reduces methamphetamine self-administration in rats.Formal Name: 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]-quinazoline. CAS Number: 1448895-09-7. Molecular Formula: C24H28N4O3. Formula Weight: 420.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: >100mM. lambdamax: 250, 318, 342 nm. SMILES: COC1=C(OC)C=C(C(N2CCN(C3=CC=CC=C3OC)CC2)=NC(C4CC4)=N5)C5=C1. InChi Code: InChI=1S/C24H28N4O3/c1-29-20-7-5-4-6-19(20)27-10-12-28(13-11-27)24-17-14-21(30-2)22(31-3)15-18(17)25-23(26-24)16-8-9-16/h4-7,14-16H,8-13H2,1-3H3. InChi Key: SWEOAXMICIJCQC-UHFFFAOYSA-N.
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