37 products were found matching "K04211"!

Description: Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders. Target: Neurotensin Receptor. Smiles: O=C(O)C1(NC(=O)C2=NN(C=3C=CN=C4C=C(Cl)C=CC43)C(=C2)C=5C(OC)=CC=CC5OC)C6CC7CC(C6)CC1C7. References: Jolas...

Description: SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 µM). Target: Neurotensin Receptor. Smiles: COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1. References: Pinkerton AB, et al. Discovery of beta-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin...

Recombinant human NTSR1 Protein with C-terminal human Fc tag. NTSR1(Met1-Thr67) hFc(Glu99-Ala330), Protein function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a...

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Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NTSR1. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NTSR1. Antigen Species: Human

ML-314 is a neurotensin-1 receptor (NTS1) agonist. It is selective for NTS1 over NTS2 in a cell-based assay of receptor/beta-arrestin complex formation (EC50s = 2 and >80 µM, respectively) but is inactive in an NTS1 calcium flux assay (EC50 = >80 µM) indicating that, in contrast to other NTS1 agonists, it does not...

SBI-553 is a beta-arrestin-biased positive allosteric modulator (PAM) of neurotensin receptor 1 (NTSR1). It binds to NSTR1 and increases neurotensin-1 affinity for NSTR1 in HEK293 cells expressing the human receptor when used at concentrations ranging from 0.01 to 10 µM. SBI-553 (0.03-30 µM) induces beta-arrestin...

SR 48692 is an orally bioavailable allosteric antagonist of the neurotensin receptor NTS1 (Kd = 3.4 nM). SR 48692 inhibits high affinity neurotensin binding to brain tissue from guinea pig, newborn mouse, newborn human, and adult human as well as rat mesencephalic cells and HT-29 cells with IC50 values ranging from...

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Protein function: G-protein coupled receptor for the...

Endogenous neuropeptide involved in hormone release, NTS agonist.

SR 142948 is an orally bioavailable non-peptide antagonist of neurotensin receptors (NTS, IC50s = 1.19, 0.32, and 3.96 nM for human recombinant NTS receptors expressed in CHO cells, HT-29 cells, and adult rat brain membranes, respectively). It inhibits inositol phosphate formation in HT-29 cells (IC50 = 3.9 nM) and...