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ML-241 is an ATP-competitive inhibitor of the ATPase p97 (IC50 = 0.11 µM) that is selective for the D2 domain of p97. It disrupts the endoplasmic reticulum-associated degradation (ERAD) pathway, preventing the degradation of p97-dependent proteasome substrates in a reporter assay using HeLa cells (IC50 = 3.5 µM) and inducing the accumulation of ubiquitin conjugates in the nuclear plus membrane and cytosolic compartments of SW403 colon cancer cells when used at concentrations of 5 and 10 µM. Unlike the p97 inhibitor ML-240, ML-241 does not induce autophagy or apoptosis in, or inhibit the proliferation of, HCT15 and SW403 cancer cells.Formal Name: 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-4-quinazolinamine, monohydrochloride. CAS Number: 2070015-13-1. Molecular Formula: C23H24N4O . HCl. Formula Weight: 408.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, DMSO: Soluble, Water: Slightly soluble. SMILES: C1(N2C3=CC=CC=C3OCC2)=NC(NCC4=CC=CC=C4)=C(CCCC5)C5=N1.Cl. InChi Code: InChI=1S/C23H24N4O.ClH/c1-2-8-17(9-3-1)16-24-22-18-10-4-5-11-19(18)25-23(26-22)27-14-15-28-21-13-7-6-12-20(21)27,/h1-3,6-9,12-13H,4-5,10-11,14-16H2,(H,24,25,26),1H. InChi Key: DYHMHNNBOLCULH-UHFFFAOYSA-N.
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