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MK-0524 is a specific prostaglandin D2 receptor (DP1) inhibitor that functions as an inverse agonist. MK-0524 decreases niacin-induced flushing during niacin treatment of dyslipidemia and is most often studied in combination with niacin. The ability of MK-0524 to inhibit DP1 prevents PGD2-induced hyaluron synthesis, yielding beneficial results in preventing pathological changes associated with thyroid eye disease. This compound also has antithrombotic activity, displaying weak inhibitory action against the thromboxane A2 receptor, inhibiting platelet activation at high concentrations.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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