29 products were found matching "K04332"!

Recombinant CHO-K1 cells stably overexpress human prostaglandin D2 receptor 1 (DP1) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

Timapiprant is a DP2 receptor antagonist (Ki = 0. µM). It is selective for DP2 over the additional prostanoid receptors DP1, TP, EP1-4, FP, and IP (Kis = >10 µM for all). Timapiprant inhibits calcium mobilization induced by prostaglandin D2 (PGD2, Cay-12010) in CHO cells expressing human DP2 (IC50 = 0. µM). It...

Fevipiprant is a DP2/CRTH2 antagonist (Ki = 1.05 nM). It reduces shape change of eosinophils induced by prostaglandin D2 (PGD2, Cay-12010) with IC50 values of 0.4 and 0.44 nM for isolated human eosinophils and human whole blood, respectively. Fevipiprant inhibits PGD2-induced release of IL-5 and IL-13 in isolated...

Prostaglandin D2 (PGD2) binds to two receptor subtypes: DP1 and CRTH2/DP2, which are both membrane-bound G protein-coupled receptors (GPCRs) but do not have significant homology and are differentially expressed. The DP1 receptor is expressed in various tissues and cells including the brain, spleen, lungs, bone...

AZD 1981 is a DP2/CRTH2 receptor antagonist (IC50 = 3.98 nM). It is selective for DP2 over a panel of receptors, ion channels, transporters, and enzymes, including DP1, COX-1, and COX-2, at 10 µM. AZD 1981 (3-100 nM) inhibits increases in the expression of CD11b, a cell adhesion molecule, induced by...

Asapiprant is an antagonist of the prostaglandin D1 (PGD1) receptor (DP1, Ki = 0.44 nM). It is selective for DP1 over DP2, as well as the thromboxane A2 (TXA2), prostaglandin I2 (PGI2), and prostaglandin E1-4 (PGE1-4) receptors (Kis = >5,000, >4,800, >6,300, and 120->6,600 nM, respectively). Asapiprant (1 and 3...

MK-0524 is a specific prostaglandin D2 receptor (DP1) inhibitor that functions as an inverse agonist. MK-0524 decreases niacin-induced flushing during niacin treatment of dyslipidemia and is most often studied in combination with niacin. The ability of MK-0524 to inhibit DP1 prevents PGD2-induced hyaluron synthesis,...

Protein function: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. [The UniProt...

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2alpha and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 217-262aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: CNLGAMRNLY AMHRRLQRHP RSCTRDCAEP RADGREASPQ PLEELD. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test....