Miconazole (nitrate)

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14alpha-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of >256 µM against Candida spp.Formal Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole, mononitrate. CAS Number: 22832-87-7. Synonyms: NSC 169434, R 14889. Molecular Formula: C18H14Cl4N2O . HNO3. Formula Weight: 479.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 0.1 mg/ml. SMILES: ClC1=CC(Cl)=CC=C1COC(C2=C(Cl)C=C(Cl)C=C2)CN3C=NC=C3.[O-][N+](O)=O. InChi Code: InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22,2-1(3)4/h1-8,11,18H,9-10H2,(H,2,3,4). InChi Key: MCCACAIVAXEFAL-UHFFFAOYSA-N. Origin: Synthetic.