126 products were found matching "K05917"!

VT-1161 is an antifungal agent. It selectively binds to C. albicans lanosterol 14-alpha-demethylase (Kd = 39 nM), also known as cytochrome P450 (CYP) isoform CYP51, over human lanosterol 14-alpha-demethylase at 86 µM and does not inhibit human CYP2C9, CYP2C19, or CYP3A4 (IC50s = 99, 72, and 65 µM, respectively)....

Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml). It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol...

A prodrug form of ravuconazole, increases survival in a mouse model of systemic C. albicans infection. Formulation: A solid. InChI:...

Difenoconazole-d6 is intended for use as an internal standard for the quantification of difenoconazole (Cay-24053) by GC- or LC-MS. Difenoconazole is a triazole fungicide. It is active against eight F. graminearum isolates (EC50s = 1.69-19.6 mg/L) and A. sonali, F. fulva, B. cinerea, and R. solani (EC50s = 0.131,...

Lanoconazole is an imidazole antifungal agent. It is active against several strains of T. mentagrophytes and T. rubrum (mean MICs = 0. and 0. µg/ml, respectively). Lanoconazole (10 µM) inhibits S. cerevisiae beta-glucan-induced IL-8 release in primary human epidermal keratinocytes and phytohemagglutinin-induced...

An inhibitor of cytochrome P-450 in steroid biosynthesis, and an inhibitor of lipoxygenase and thromboxane synthase activities. It is classified as antineoplastic, antimetastatic, and antipsoriatic.

Fluconazole is a triazole antifungal agent that is effective against most Candida strains. In vivo fluconazole at 0.5-100 mg/kg demonstrates protective activity in various experimental animal models of systemic fungal diseases including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis,...

Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14alpha-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the...

Voriconazole-d3 is intended for use as an internal standard for the quantification of voriconazole (Cay-15633) by GC- or LC-MS. Voriconazole is a triazole antifungal agent and a derivative of fluconazole (Cay-11594). It is active against a variety of yeast and fungi, including clinical isolates of A. flavus, A....

Fluconazole-d4 is intended for use as an internal standard for the quantification of fluconazole (Cay-11594) by GC- or LC-MS. Fluconazole is a triazole antifungal agent that is effective against most Candida strains. In vivo, fluconazole at 0.5-100 mg/kg demonstrates protective activity in various experimental...

Econazole (nitrate) is an azole-based antifungal compound that acts by inhibiting the 14alpha-demethylation of lanosterol (Cay-19521), which consequently leads to the inhibition of ergosterol (Cay-19850) synthesis in fungal cell membranes. It demonstrates broad-spectrum activity against dermatophytes, Candida...

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14alpha-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a...