Mibefradil (hydrochloride)

Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 µM, respectively). It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM. Mibefradil has minimal negative inotropic effects, supporting its use as an anti-hypertensive agent.Formal Name: (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester 2-methoxy-acetic acid, dihydrochloride. CAS Number: 116666-63-8. Synonyms: Posicor, Ro 40-5967. Molecular Formula: C29H38FN3O3 . 2HCl. Formula Weight: 568.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml, Ethanol: 16 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 242, 270, 276 nm. SMILES: CN(CCCC1=NC2=C(C=CC=C2)N1)CC[C@]([C@H]3C(C)C)(CCC4=CC(F)=CC=C34)OC(COC)=O.Cl.Cl. InChi Code: InChI=1S/C29H38FN3O3.2ClH/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26,,/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32),2*1H/t28-,29-,,/m0../s1. InChi Key: MTJLQTFHJIHXIX-GDUXWEAWSA-N.