MHY553

MHY553 is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha). It activates PPARalpha in HepG2 cells in a reporter assay when used at a concentration of 1 µM but does not activate PPARbeta or PPARgamma at 10 µM. MHY553 (3 µM) prevents triglyceride accumulation induced by the liver X receptor (LXR) agonist T0901317 (Cay-71810) in HepG2 cells, as well as scavenges reactive oxygen species (ROS) and peroxynitrite in cell-free assays (IC50s = 39.7 and 2.39 µM, respectively). It also inhibits beta-glucuronidase and tyrosinase (IC50s = 8.9 and 0.01 µM for the bovine liver and mushroom enzymes, respectively). MHY553 (5 mg/kg) reduces age-induced increases in liver weight and triglyceride levels in a rat model of hepatic steatosis.Formal Name: 4-(2-benzothiazolyl)-1,3-benzenediol. CAS Number: 6265-56-1. Synonyms: NSC 33005. Molecular Formula: C13H9NO2S. Formula Weight: 243.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 24.5 mg/ml. lambdamax: 219, 336 nm. SMILES: OC1=CC(O)=C(C2=NC3=CC=CC=C3S2)C=C1. InChi Code: InChI=1S/C13H9NO2S/c15-8-5-6-9(11(16)7-8)13-14-10-3-1-2-4-12(10)17-13/h1-7,15-16H. InChi Key: YQIRLDMXXRINIJ-UHFFFAOYSA-N.