153 products were found matching "K07294"!

Peroxisome proliferator activated receptor alpha(PPARA) Homo sapiens Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers, this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in...

The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation. GW 6471 is an antagonist of PPARalpha (IC50 = 240 nM). It drives the displacement of coactivators...

Wy 14643 is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha). It selectively transactivates PPARalpha over PPARgamma in a reporter assay using CV-1 mouse fibroblasts when used at a concentration of 100 µM. Wy 14643 (2 mg/kg) decreases distal colon protein levels of IFN-gamma, TNF-alpha,...

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the large family of nuclear hormone receptors. There are three subtypes, PPARalpha, beta/delta, and gamma, which are expressed at variable levels in different tissues. The Cayman Chemical PPARalpha...

Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARalpha results in expression of a variety of genes, particularly those involved in fatty acid beta-oxidation, binding, and transport. GW 7647 is a...

Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor alpha (PPARalpha, EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis. It is selective for PPARalpha over PPARdelta and PPARgamma (EC50s =...

Solulibility: Ethanol: Sparingly Soluble: 1-10 mg/ml: .

Anti-NASH agent 1 is an anti-non-alcoholic steatohepatitis (NASH) agent and a derivative of the PPARalpha and PPARdelta agonist GFT505 (elafibranor, Cay-23508). It inhibits free fatty acid-induced triglyceride accumulation and aspartate aminotransferase (AST) activity in HepG2 cells when used at a concentration of...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor alpha (NR1C1), a ligand-dependent transcription factor commonly referred to as PPARA or PPARalpha. INDIGO's reporter cells include...

Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARalpha, PPARbeta, and PPARgamma, respectively, for transactivation activity. It increases beta-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and...

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor family of ligand-activated transcription factors that regulates a variety of metabolic functions and inflammation. It contains an N-terminal domain that is subject to phosphorylation, a DNA-binding domain, and a...

Fenofibric acid is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), PPARgamma, and PPARdelta (EC50s = 22.4, 1.47, and 1.06 µM, respectively, in a transactivation assay) and an active metabolite of the PPARalpha agonist fenofibrate (Cay-10005368). It is formed by the hydrolysis of...