Methoxy-X04

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-beta (Abeta) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar beta-sheet deposits and is used to image Abeta plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.Formal Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol. CAS Number: 863918-78-9. Molecular Formula: C23H20O3. Formula Weight: 344.4. Purity: >95%. Emission: 460-500 nm. Excitation: 750 nm (2-photon excitation). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 5 mg/ml. lambdamax: 371 nm. SMILES: OC1=CC=C(/C=C/C2=CC=C(/C=C/C3=CC=C(O)C=C3)C(OC)=C2)C=C1. InChi Code: InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+. InChi Key: FGYNZFHVGOFCMD-KHVHPYDTSA-N.