Mesoridazine

Mesoridazine is an active metabolite of the typical antipsychotic thioridazine (Cay-14400). It is formed via sulfoxidation of thioridazine by the cytochrome P450 (CYP) isoform CYP2D6 in human liver microsomes. It binds to histamine H1, dopamine D2, muscarinic acetylcholine, and alpha1- and alpha2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively). Mesoridazine (10, 30, and 45 mg/kg, i.p.) prevents mescaline-induced hyperactivity in mice.Formal Name: 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine. CAS Number: 5588-33-0. Synonyms: NSC 186066. Molecular Formula: C21H26N2OS2. Formula Weight: 386.6. Purity: >95%. Formulation: (Request formulation change), A solution in acetonitrile. Solubility: Acetonitrile: slightly soluble, DMSO: slightly, heated, Methanol: slightly soluble. SMILES: O=S(C)C1=CC=C2SC3=C(N(CCC4N(CCCC4)C)C2=C1)C=CC=C3O=S(C)C1=CC=C2SC3=C(N(CCC4N(CCCC4)C)C2=C1)C=CC=C3. InChi Code: InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3. InChi Key: SLVMESMUVMCQIY-UHFFFAOYSA-N.