Meclofenamate (sodium salt)

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.Formal Name: 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, monosodium salt. CAS Number: 6385-02-0. Synonyms: Meclofenamic Acid. Molecular Formula: C14H10Cl2NO2 . Na. Formula Weight: 318.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >39 mg/ml, DMSO: >75 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): <50 µg/ml, PBS (pH 9.0): >50 mg/ml. SMILES: ClC1=C(N([H])C2=C(C([O-])=O)C=CC=C2)C(Cl)=C(C)C=C1.[Na+]. InChi Code: InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19,/h2-7,17H,1H3,(H,18,19),/q,+1/p-1. InChi Key: OGPIIGMUPMPMNT-UHFFFAOYSA-M.