Meclizine (hydrochloride)

Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.Formal Name: 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine, dihydrochloride. CAS Number: 1104-22-9. Synonyms: Meclozine, NSC 28728. Molecular Formula: C25H27ClN2 . 2HCl. Formula Weight: 463.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 0.1 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 229 nm. SMILES: CC1=CC=CC(CN(CC2)CCN2C(C3=CC=CC=C3)C4=CC=C(Cl)C=C4)=C1.Cl.Cl. InChi Code: InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23,,/h2-13,18,25H,14-17,19H2,1H3,2*1H. InChi Key: VCTHNOIYJIXQLV-UHFFFAOYSA-N.