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Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as clinical trials show that it decreases blood pressure and proteinuria and prevents right ventricle hypertrophy. In models of systemic sclerosis, macitentan slowed the fibrotic process. In other animal models, macitentan enhanced toxicity of a variety of other chemotherapeutics, increasing apoptosis in tumor cells and decreasing levels of phosphorylated VEGFR2, phosphorylated Akt, and MAPK.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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