62 products were found matching "K04198"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. EDNRB antibody detects Endothelin receptor type B, encoded by the EDNRB gene on chromosome 13q22.3. EDNRB antibody is commonly used in vascular biology, developmental biology, and oncology. EDNRB is a G protein-coupled receptor (GPCR) for...

Recombinant CHO-K1 cells stably overexpress human endothelin receptor type B (EDNRB) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

An ETA and ETB antagonist (IC50s = 220 and 160 nM, respectively), inhibits endothelin-1-induced secretion of arachidonic acid in primary rat mesangial cells (IC50 = 1.8 µM), prevents sarafotoxin S6-induced relaxation in preconstricted rat mesenteric arteries (pA2 = 6.47), increases cerebral blood flow in a rat model...

Solulibility: DMSO: Sparingly Soluble: 1-10 mg/ml: .

Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...

White to off-white solid. Soluble in DMSO, 0.1M sodium bicarbonate or 100% ethanol. Slightly soluble in methanol. Insoluble in water. Potent and selective endothelin B receptor (ETBR) antagonist.

BQ-788 is a peptide endothelin type B (ETB) receptor antagonist (IC50 = 1.2 nM). It is selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM. BQ-788 inhibits calcium mobilization induced by endothelin-1 (ET-1) in human Girrardi heart cells (IC50...

Bosentan-d4 is an internal standard for the quantification of bosentan (Cay-11731) by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name:...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Endothelin receptor type B, also known as ETB, is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand,...

Antibiotic, Potent endothelin receptor antagonist, Anti-osteoporotic, Antibacterial, Cytotoxic, Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Isolated from Streptomyces violaceoruber.

Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as...