This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective inhibitor of TGF-beta RI (TGFR-I, TbetaR-I, ALK-5), with an IC50 value of 59 nM. LY364947 less effectively inhibits TGF-beta RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and mixed-lineage kinase 7 (MLK7, IC50 = 1,400 nM). It inhibits TGF-beta-induced cell growth (IC50 = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-beta-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.Formal Name: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline. CAS Number: 396129-53-6. Synonyms: HTS 466284, TGF-beta RI Kinase Inhibitor. Molecular Formula: C17H12N4. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 229, 283 nm. SMILES: C1(C2=CC=NC3=C2C=CC=C3)=CNN=C1C4=NC=CC=C4. InChi Code: InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21). InChi Key: IBCXZJCWDGCXQT-UHFFFAOYSA-N.
Keywords:
HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information