Lubiprostone

Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1, Cay-13010). It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels. Lubiprostone (1 µM) induces short-circuit currents, a marker of transepithelial chloride transport, in T84 intestinal cells. Lubiprostone (48 µg/animal, p.o.) increases postprandial antral contractions and decreases postprandial small bowel transit time in dogs. Formulations containing lubiprostone have been used in the treatment of irritable bowel syndrome with constipation.Formal Name: 16,16-difluoro-11alpha-hydroxy-9,15-dioxo-prostan-1-oic acid. CAS Number: 136790-76-6. Synonyms: RU-0211, SPI-0211. Molecular Formula: C20H32F2O5. Formula Weight: 390.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H]2[C@H](OC(O)C(C(F)(F)CCCC)C2)C1. InChi Code: InChI=1S/C20H32F2O5/c1-2-3-10-20(21,22)15-11-14-13(8-6-4-5-7-9-18(24)25)16(23)12-17(14)27-19(15)26/h13-15,17,19,26H,2-12H2,1H3,(H,24,25)/t13-,14-,15?,17-,19?/m1/s1. InChi Key: UFMXVXDWWQKSHH-HORNASKESA-N.